I wouldn't want to try this with the HD version. But with the original 2001 game from gog.com I get 50+ fps at all times with all settings cranked to the max in 1080p.
I can play Spore in 720p mostly without issues. I even upped the texture and world details to high without seeing much of a drop in framerate. I do get occasional drops and hitches. But nothing close to game breaking. The most severe one seems to be in the company logo when starting the game. This one did quite surprise me as Maxis is also behind one of my favourite games that I sadly still haven't found the computer that can run smoothly: SimCity 4.
I can get Slime Rancher to run at a frame rate of about 20-30 when I turn all settings to their lowest and run it in 800x600 at most times. It does drop even further down when at my home when I get to have more than just a couple of corrals for my slimes. 15-20 seems to be the norm here and it does sometimes go into single digits. Furthermore if I run the game normally when windows is in 1920x1080 the game just uses an internal renderer of 800x600 but still displays 1920x1080 and this does have an influence on performance as well as just making the game look even worse because of the scaling taking place. Because of this I use nircmd to set the desktop resolution to 800x600 before running the game.